Attentional bias towards appealing and disgusting food cues varies with the menstrual cycle.

Ovarian hormonal changes along the female menstrual cycle are believed to adapt women to the external environment through various adaptive strategies, including modulating appetite and eating behavior. We aimed to compare food-associated behavioral responses between two distinct menstrual phases (late follicular vs. mid-luteal) and investigate the underlying neural mechanism. Attentional bias towards visual food cues was repeatedly measured in 29 healthy young women during these two menstrual phases in a counterbalanced manner. Combining an emotional dot-probe task with frequency-tagged electroencephalography (EEG), we confirmed that the menstrual cycle modulated healthy women's attentional bias towards appealing and disgusting food cues. Women in the mid-luteal phase showed more avoidance of disgusting food cues, as reflected by a significantly longer response time. Steady-state visual evoked potential (SSVEP) results indicated that they exhibited a trend of transiently enhanced attentional bias towards appealing food cues and another trend of speeded attentional withdrawal from disgusting food cues during the mid-luteal phase relative to the late follicular phase, albeit non-significant after correction for multiple testing. Moreover, a significantly larger P3 amplitude was evoked by probes following the presentation of disgusting food cues in the mid-luteal phase than the late follicular phase. These findings indicate divergent attentional deployments on emotional food cues across menstrual phases and suggest the mid-luteal phase as a relatively sensitive stage in the menstrual cycle for women to regulate their appetite and eating behavior.

Mid-Luteal Olfactory Abilities Reveal Healthy Women's Emotional and Cognitive Functions.

Ovarian hormones modulate women's physical and psychological states periodically. Although the olfactory function is increasingly recognized as a reflection of physical and mental health conditions in the clinic, the role of olfaction in emotional and cognitive functions for healthy individuals has yet to be elucidated, especially when taking the menstrual cycle into account. We carried out a comprehensive investigation to explore whether the menstrual cycle could modulate women's olfactory function and whether healthy women's emotional symptoms and behavioral impulsivity could be characterized by their olfactory abilities at a specific menstrual cycle stage. Twenty-nine healthy young women were evaluated repeatedly using a standard olfactory test battery during the late follicular and mid-luteal phases. Their emotional symptoms and behavioral impulsivity were separately quantified via psychometric scales and a stop-signal task. We observed enhanced olfactory discrimination performance during the mid-luteal phase than the late follicular phase. We also found that women's better olfactory discrimination and worse olfactory threshold in the mid-luteal phase predicted fewer individual emotional symptoms and lower behavioral impulsivity, respectively. These relationships were nonetheless absent in the late follicular phase. Our data extend previous clinical observations of the coexistence of olfactory deficits and neuropsychiatric disorders, providing new insights into the significance of olfaction and ovarian hormones for emotional and cognitive functions.